The Tuticorin Airport is at Vagaikulam, 14 km (9 mile) from the heart of the city.
Thoothukudi Railway station comes under Southern Railway Division, connected with Chennai, Mysore, Coimbatore, okha and Tirunelveli.
The major roads within the city are NH7A connecting Palayamkottai, Ettayapuram road (also called Madurai road). National Highway 45B (India) connecting Ramanathapuram road or East Coast Road, Thiruchendur road. Thoothukudi being a harbour city has lot of container truck transport is also available.